Tennessee Retina is an active participant in many national research trials. The efforts of our physicians and patients have led to the approval of many treatments now considered to be the standard of care, and our continuing involvement in clinical research offers access to new and potentially superior treatments to patients with sight-threatening conditions.

As with all patients, our clinical trial patients are very important to us, and we provide them with exceptional care and attention. Please contact your current eyecare provider to see if you may qualify for one of our studies, or contact one of our Clinical Trial staff members with any questions at (615) 983-6000.

Diabetes in the Eyes

INSIGHT (Enrolling)
NCT03610646  Clinical
A Multi Center, Randomized, Double-Masked, Active-Controlled, Comparative Clinical Study to Evaluate the Efficacy and Safety of MYL-1701P and Eylea® in Subjects With Diabetic Macular Edema

RHINE GR40398 (Enrolling)
NCT03622593  Clinical
A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of RO6867461 in Patients With Diabetic Macular Edema


Age-Related Macular Degeration (AMD)

PANDA (Enrolling)
NCT03577899 Clinical
A Multicenter, Double-Masked, Randomized, Dose-Ranging Trial to Evaluate the Efficacy and Safety of Conbercept Intravitreal Injection in Subjects with Neovascular Age-Related Macular Degeneration.

TENAYA (Enrolling)
NCT03823287 Clinical
A Phase III, multicenter, randomized, single-masked, active comparator controlled study to evaluate RO6867461 in patients with Neovascular Age-Related Macular Degeneration.

GALLEGO (Enrolling Soon)
NCT03972709 Clinical
A Phase II, multicenter, randomized, single-masked, sham injection-controlled study of the safety, tolerability, and evidence of activity of intravitreal injection of RO7171009 in patients with Geographic Atrophy secondary to age-related macular degeneration

SPIAM (Enrolling)
NCT03891875 Clinical
A Phase 2, Randomized, Double-Masked, Placebo-Controlled Clinical Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Subcutaneous Elamipretide Solution in Subjects with Age-Related Macular Degeneration with Geographic Atrophy

ADVM-022-01 (Enrolling)
NCT03748784  Clinical
An Open Label Phase 1 Study of ADVM-022 (AAV.7m8-aflibercept) in Neovascular (Wet) Age-Related Macular Degeneration

ASTELLAS (Enrolling)
NCT03178149  Clinical
A Staged Study Incorporating a Phase 1b, Multicenter, Unmasked, Dose Escalation Evaluation of Safety and Tolerability and a Phase 2, Multicenter, Unmasked, Randomized, Parallel Group, Controlled, Proof of Concept Investigation of Efficacy and Safety of ASP7317 for Atrophy Secondary to Age-related Macular Degeneration

ARCHWAY - GR40548 (Active, Enrollment Closed)
NCT03677934  Clinical
Phase III, Multicenter, Randomized, Visual Assessor-Masked, Active-Comparator Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration

TRISTAR (Active, Enrollment Closed)
NCT03468296  Clinical
Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept

PORTAL - LADDER EXT GR40549 (Active, Enrollment Closed)
NCT03683251  Clinical
A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration


Vein Occlusion

SCORE 2 (Active, Enrollment Closed)
NCT01969708  Clinical
Study of Comparative Treatments for Retinal Vein Occlusion 2 [SCORE2]: a Multicenter, Prospective, Randomized Non-inferiority Trial of Eyes With Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab Every 4 Weeks With Intravitreal Aflibercept Every 4 Weeks.

RAVEN (Enrolling soon)
NCT03810313 Clinical
An Eighteen-Month, Two-Arm, Randomized, Double- Masked, Multi-center, Phase III Study Assessing the Efficacy and Safety of Brolucizumab versus Aflibercept in Adult Patients with Visual Impairment due to Macular Edema secondary to Branch Retinal Vein Occlusion

"Very friendly staff, wife had an issue with her eyes, they helped us feel comfortable and put us at ease, waiting areas were spacious and did not feel cramped with people... we did not wait long to be seen. Staff was knowledgeable and friendly and positive atmosphere."

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